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Submit ReviewGR 64349
说明： Potent, selective NK2 agonist
纯度： ≥95% (HPLC)
生物活性 for GR 64349
GR 64349 is a potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for GR 64349
| 分子量 | 921.12 |
| 公式 | C42H68N10O11S |
| 序列 |
KDSFVGLM (Modifications: Leu-7 = R-γ-lactam-Leu, Met-8 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 137593-52-3 |
| PubChem ID | 5311135 |
| InChI Key | HVUNRXRFMQDMBO-BPZYSUIOSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NC1CCN([C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GR 64349
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for GR 64349
参考文献 for GR 64349
参考文献是支持产品生物活性的出版物。
Chang et al (2000) Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J.Pharmacol.Exp.Ther. 294 147 PMID: 10871306
Chizh et al (1995) Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord. Br.J.Pharmacol. 115 1013 PMID: 7582497
Deal et al (1992) Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J.Med.Chem. 35 4195 PMID: 1331460
If you know of a relevant reference for GR 64349, please let us know.
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关键词: GR 64349, GR 64349 supplier, Potent, selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, GR64349, GlaxoSmithKline, GSK, Receptor, 1668, Tocris Bioscience
3 篇 GR 64349 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GR 64349 的部分引用包括：
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241
Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576 PMID: 25490143
Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Sci Rep 156 627 PMID: 25422875
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