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Submit ReviewGR 94800
说明： Potent, selective NK2 antagonist
纯度： ≥95% (HPLC)
生物活性 for GR 94800
GR 94800 is a potent and selective tachykinin NK2 receptor antagonist (pKB values are 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors respectively). Active in vivo.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for GR 94800
| 分子量 | 904.08 |
| 公式 | C49H61N9O8 |
| 序列 |
AAWFPPX (Modifications: Ala-1 = N-(Bz)Ala, Trp-3 = D-Trp, Pro-5 = D-Pro, X = Nle with C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 141636-65-9 |
| PubChem ID | 5487475 |
| InChI Key | CWEISCOCKRHHOU-UJYVDGJVSA-N |
| Smiles | [H]N([C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCC)C(N)=O)C(=O)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GR 94800
参考文献 for GR 94800
参考文献是支持产品生物活性的出版物。
Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274
McElroy et al (1992) Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J.Med.Chem. 35 2582 PMID: 1321907
Zagorodnyuk et al (1995) Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum. Br.J.Pharmacol. 115 237 PMID: 7545517
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关键词: GR 94800, GR 94800 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, GR94800, GlaxoSmithKline, GSK, Receptor, 1667, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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