Granisetron hydrochloride

Cat. No. 2903 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： 5-HT₃ antagonist

别名： BRL 43694

化学名： 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

纯度： ≥99% (HPLC)

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Granisetron hydrochloride

Granisetron hydrochloride is a 5-HT₃ receptor antagonist that possesses potent antiemetic activity.

技术数据 for Granisetron hydrochloride

分子量	348.87
公式	C₁₈H₂₄N₄O.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	107007-99-8
PubChem ID	65264
InChI Key	QYZRTBKYBJRGJB-UHFFFAOYSA-N
Smiles	O=C(C3=NN(C)C4=C3C=CC=C4)NC1CC(N2C)CCCC2C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Granisetron hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	34.89	100
	DMSO	3.49	10

制备储备液 for Granisetron hydrochloride

以下数据基于产品分子量 348.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.33 mL	28.66 mL
5 mM	0.57 mL	2.87 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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产品说明书 for Granisetron hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Granisetron hydrochloride

参考文献是支持产品生物活性的出版物。

Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine₃ receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113 PMID: 2540014

Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805 PMID: 1723376

Martin et al (1998) Anti-emetic effect of ondans. and granis. after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631

If you know of a relevant reference for Granisetron hydrochloride, please let us know.

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关键词: Granisetron hydrochloride, Granisetron hydrochloride supplier, 5-HT3, antagonists, Serotonin, Receptors, BRL43694, BRL, 43694, 2903, Tocris Bioscience

4 篇 Granisetron hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Granisetron hydrochloride 的部分引用包括：

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Carlson and Fieber (2012) Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica. Comp Biochem Physiol C Toxicol Pharmacol 155 151 PMID: 21497673

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Neuropharmacology 7 2336 PMID: 26114334

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