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Submit ReviewGSA 10
说明： Smo receptor agonist
化学名： 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
纯度： ≥98% (HPLC)
生物活性 for GSA 10
GSA 10 is a smoothened (Smo) receptor agonist (EC50 = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Displays anti-adipogenic effects in vitro, mediated by a non-canonical Hedgehog signaling pathway. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
技术数据 for GSA 10
| 分子量 | 450.53 |
| 公式 | C26H30N2O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 300833-95-8 |
| PubChem ID | 54683103 |
| InChI Key | MDLUYYGRCGDKGL-UHFFFAOYSA-N |
| Smiles | OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GSA 10
参考文献 for GSA 10
参考文献是支持产品生物活性的出版物。
Gorojankina et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 83 1020 PMID: 23448715
Fleury et al (2016) Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci.Rep. 24 23479 PMID: 27010359
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关键词: GSA 10, GSA 10 supplier, GSA10, Smoothened, Smo, receptors, agonists, differentiation, multipotent, mesenchymal, progenitor, cells, osteoblasts, osteogenic, Receptors, Mesenchymal, Stem, Cells, Osteogenic, 4918, Tocris Bioscience
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