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GSK 1363089

Cat. No. 6056 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6056 has been discontinued.

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说明： Potent inhibitor of MET, VEGFR2, Ron and AXL
别名： XL 880,EXEL 2880,Foretinib
化学名： N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for GSK 1363089

GSK 1363089 is a potent inhibitor of MET, VEGFR2, Ron and AXL (IC50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRα and PDGFRβ. Inhibits migration and invasion of B16F10 melanoma cells in vitro. Suppresses B16F10 tumor growth and metastasis in mice. Orally available.

技术数据 for GSK 1363089

分子量 632.65
公式 C34H34F2N4O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 849217-64-7
PubChem ID 42642645
InChI Key CXQHYVUVSFXTMY-UHFFFAOYSA-N
Smiles COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCN6CCOCC6

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for GSK 1363089

参考文献是支持产品生物活性的出版物。

Myers et al (2016) AXL inhibitors in cancer: A medicinal chemistry perspective. J.Med.Chem. 59 3593 PMID: 26555154

Faria et al (2015) Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma. Cancer Res. 75 134 PMID: 25391241

Qian et al (2009) Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 69 8009 PMID: 19808973

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关键词: GSK 1363089, GSK 1363089 supplier, GSK1363089, potent, inhibitors, inhibits, HGF, VEGFR2, AXL, tyrosine, kinases, orally, available, XL880, EXEL2880, XL, 880, EXEL, 2880, Foretinib, MET, Receptors, VEGFR, FLT3, PDGFR, 6056, Tocris Bioscience

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