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GSK 2239633A

Cat. No. 7071 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent CCR4 antagonist
化学名： N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 2239633A

GSK 2239633A is a potent CCR4 antagonist (pIC50 = 7.83 in a 35S-GTPγS competition assay). Inhibits thymus activation-regulated chemokine (TARC) -induced F-actin polymerization in human whole blood.

技术数据 for GSK 2239633A

分子量 549.06
公式 C24H25ClN4O5S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1240516-71-5
PubChem ID 46861584
InChI Key YTEVTHHGQMUPHC-UHFFFAOYSA-N
Smiles COC1=C2C(NS(=O)(C3=CC=C(S3)Cl)=O)=NN(C2=CC=C1)CC4=CC(CNC(C(C)(O)C)=O)=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 2239633A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.91 100

制备储备液 for GSK 2239633A

以下数据基于产品分子量 549.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.82 mL 9.11 mL 18.21 mL
5 mM 0.36 mL 1.82 mL 3.64 mL
10 mM 0.18 mL 0.91 mL 1.82 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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参考文献 for GSK 2239633A

参考文献是支持产品生物活性的出版物。

Procopiou et al (2012) Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation. Bioorg.Med.Chem.Lett. 22 2730 PMID: 22437117

If you know of a relevant reference for GSK 2239633A, please let us know.

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关键词: GSK 2239633A, GSK 2239633A supplier, GSK2239633A, CCR4, antagonists, antagonism, potent, TARC, CCL17, thymus, activation-regulated, chemokines, CCL22, macrophage-derived, MDC, Chemokine, CC, Receptors, 7071, Tocris Bioscience

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