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GSK 2833503A

Cat. No. 6497 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective TRPC6 and TRPC3 antagonist
化学名： [2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2S,3S)-2,3-dimethyl-1-piperidinyl]methanone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 2833503A

GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cells in vitro and in cardiomyocytes.

化合物库 for GSK 2833503A

GSK 2833503A is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 2833503A

分子量 381.89
公式 C18H21ClFN3OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1366234-01-6
PubChem ID 71818575
InChI Key ODUIXUGXPFKQLG-QWRGUYRKSA-N
Smiles C[C@H]1CCCN(C(C2=C(SC(NC3=C(C=C(C=C3)Cl)F)=N2)C)=O)[C@H]1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 2833503A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.19 100
ethanol 7.64 20

制备储备液 for GSK 2833503A

以下数据基于产品分子量 381.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.09 mL 26.19 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for GSK 2833503A

参考文献是支持产品生物活性的出版物。

Washburn et al (2013) The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg.Med.Chem.Lett. 23 4979 PMID: 23886683

Seo et al (2014) Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc.Natl.Acad.Sci.U.S.A. 111 1551 PMID: 24453217

If you know of a relevant reference for GSK 2833503A, please let us know.

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关键词: GSK 2833503A, GSK 2833503A supplier, GSK2833503A, GSK503A, TRPC3, TRPC6, transient, receptor, potential, canonical, channel, anatagonists, potent, selective, TRPC, 6497, Tocris Bioscience

1 篇 GSK 2833503A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 2833503A 的部分引用包括：

Jonathan H et al (2022) Genetic- and diet-induced ω-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice. Cell Rep 40 111306 PMID: 36070688

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