GSK 4112

Cat. No. 3663 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective Rev-Erbα agonist

别名： SR 6452

化学名： 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GSK 4112

GSK 4112 is a selective Rev-Erbα agonist (EC₅₀ = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.

化合物库 for GSK 4112

GSK 4112 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 4112

分子量	396.89
公式	C₁₈H₂₁ClN₂O₄S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1216744-19-2
PubChem ID	50905018
InChI Key	WYSLOKHVFKLWOU-UHFFFAOYSA-N
Smiles	CC(C)(C)OC(CN(CC2=CC=C(Cl)C=C2)CC1=CC=C([N+]([O-])=O)S1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 4112

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.92	25

制备储备液 for GSK 4112

以下数据基于产品分子量 396.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	10.08 mL	50.39 mL	100.78 mL
1.25 mM	2.02 mL	10.08 mL	20.16 mL
2.5 mM	1.01 mL	5.04 mL	10.08 mL
12.5 mM	0.2 mL	1.01 mL	2.02 mL

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产品说明书 for GSK 4112

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GSK 4112

参考文献是支持产品生物活性的出版物。

Meng et al (2008) Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 121 3629 PMID: 18946026

Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 6 131 PMID: 21043485

If you know of a relevant reference for GSK 4112, please let us know.

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关键词: GSK 4112, GSK 4112 supplier, GSK4112, REV-ERBA, REV-ERBα, REV-ERBalpha, agonists, circadian, rhythms, SR6452, SR, 6452, Rev-Erb, Receptors, 3663, Tocris Bioscience