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GSK 9027

Cat. No. 4116 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Glucocorticoid receptor agonist
化学名： N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 9027

GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for GSK 9027

分子量 525.52
公式 C27H19F4N3O2S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1229096-88-1
PubChem ID 24882669
InChI Key DXBJGDVBQPEMOB-UHFFFAOYSA-N
Smiles FC(C=C3)=CC=C3N2C1=CC=C(C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=C1C=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 9027

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.55 100

制备储备液 for GSK 9027

以下数据基于产品分子量 525.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.51 mL 19.03 mL
5 mM 0.38 mL 1.9 mL 3.81 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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产品说明书 for GSK 9027

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for GSK 9027

参考文献是支持产品生物活性的出版物。

Yates et al (2010) Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J.Med.Chem. 53 4531 PMID: 20469868

If you know of a relevant reference for GSK 9027, please let us know.

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关键词: GSK 9027, GSK 9027 supplier, gsk, GSK9027, glucocorticoid, receptors, agonists, Glucocorticoid, Receptor, 4116, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.