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Submit ReviewGSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.
Sold for research purposes under agreement from GlaxoSmithKline.
分子量 | 525.52 |
公式 | C27H19F4N3O2S |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 1229096-88-1 |
PubChem ID | 24882669 |
InChI Key | DXBJGDVBQPEMOB-UHFFFAOYSA-N |
Smiles | FC(C=C3)=CC=C3N2C1=CC=C(C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=C1C=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 52.55 | 100 |
以下数据基于产品分子量 525.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.9 mL | 9.51 mL | 19.03 mL |
5 mM | 0.38 mL | 1.9 mL | 3.81 mL |
10 mM | 0.19 mL | 0.95 mL | 1.9 mL |
50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
参考文献是支持产品生物活性的出版物。
Yates et al (2010) Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J.Med.Chem. 53 4531 PMID: 20469868
If you know of a relevant reference for GSK 9027, please let us know.
关键词: GSK 9027, GSK 9027 supplier, gsk, GSK9027, glucocorticoid, receptors, agonists, Glucocorticoid, Receptor, 4116, Tocris Bioscience
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.