Glucocorticoid Receptors
Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.
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Glucocorticoid Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 3685 | Corticosterone |
| Endogenous glucocorticoid | |
| 2007 | Fluticasone propionate |
| Selective high affinity glucocorticoid receptor agonist | |
| 4116 | GSK 9027 |
| Glucocorticoid receptor agonist | |
| 4819 | Methylprednisolone |
| Glucocorticoid receptor agonist | |
Glucocorticoid Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 1479 | Mifepristone |
| Glucocorticoid and progesterone receptor antagonist | |
Other |
|
| Cat. No. | Product Name / Activity |
| 2671 | Budesonide |
| Synthetic glucocorticoid; anti-inflammatory and chemopreventive | |
| 6357 | Ciclesonide |
| Glucocorticoid antiasthmatic prodrug | |
| 1126 | Dexamethasone |
| Anti-inflammatory glucocorticoid | |
| 4093 | Hydrocortisone |
| Adrenal glucocorticoid; immunosuppressant | |
Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by GRs is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.
GRs are ubiquitously expressed and mediate a vast array of physiological functions. Glucocorticoids regulate carbohydrate, protein and fat metabolism, modulate immune responses through supression of chemokine and cytokine production and have critical roles in constitutive activity of the CNS, digestive, hematopoietic, renal and reproductive systems. The human gene encoding the glucocorticoid receptor has been localized to 5q31-q32.
External sources of pharmacological information for Glucocorticoid Receptors :
Literature for Glucocorticoid Receptors
Tocris offers the following scientific literature for Glucocorticoid Receptors to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Written by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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