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GT 949

Cat. No. 6578 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective positive allosteric modulator of EAAT2
化学名： 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GT 949

GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.

化合物库 for GT 949

GT 949 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GT 949

分子量 527.66
公式 C30H37N7O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 460330-27-2
PubChem ID 3195790
InChI Key ZVWPOIUAPXDLMB-UHFFFAOYSA-N
Smiles COC1=CC=C2NC(C(C(C3=NN=NN3CCC4=CC=CC=C4)N5CCN(C6CCCCC6)CC5)=CC2=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GT 949

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.77 100

制备储备液 for GT 949

以下数据基于产品分子量 527.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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参考文献 for GT 949

参考文献是支持产品生物活性的出版物。

Kortagere et al (2018) Identification of novel allosteric modulators of glutamate transporter EAAT2. ACS Chem.Neurosci. 9 522 PMID: 29140675

Falcucci et al (2019) Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model. ACS Chem.Neurosci. 10 3437 PMID: 31257852

If you know of a relevant reference for GT 949, please let us know.

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关键词: GT 949, GT 949 supplier, GT949, selective, EAAT2, positive, allosteric, modulators, PAM, Glutamate, Transporters, 6578, Tocris Bioscience

1 篇 GT 949 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GT 949 的部分引用包括：

Zhang et al (2019) Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors. Cell Rep 27 2871 PMID: 31167134

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Huntington's Disease Poster

Huntington's Disease Poster

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.