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Submit ReviewGTP 14564
说明： Class III receptor tyrosine kinase (RTK) inhibitor
化学名： 3-Phenyl-1H-benzofuro[3,2-c]pyrazole
纯度： ≥99% (HPLC)
生物活性 for GTP 14564
GTP 14564 is a potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Displays no activity against ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μM). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukemic.
技术数据 for GTP 14564
| 分子量 | 234.26 |
| 公式 | C15H10N2O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 34823-86-4 |
| PubChem ID | 3385203 |
| InChI Key | DZQLVVLATXPWBK-UHFFFAOYSA-N |
| Smiles | N1N=C(C2=C1C1=C(O2)C=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GTP 14564
参考文献 for GTP 14564
参考文献是支持产品生物活性的出版物。
Murata et al (2003) Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J.Biol.Chem. 278 32892 PMID: 12815052
Yao et al (2005) Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia 19 1605 PMID: 16034464
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关键词: GTP 14564, GTP 14564 supplier, Class, III, receptor, tyrosine, kinase, RTKs, inhibitors, inhibits, Receptors, GTP14564, Other, 2086, Tocris Bioscience
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