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GW 2580

Cat. No. 5673 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective cFMS kinase inhibitor; orally bioavailable
化学名： 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GW 2580

GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.

技术数据 for GW 2580

分子量 366.41
公式 C20H22N4O3
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 870483-87-7
PubChem ID 11617559
InChI Key MYQAUKPBNJWPIE-UHFFFAOYSA-N
Smiles NC1=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=NC(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GW 2580

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.32 50

制备储备液 for GW 2580

以下数据基于产品分子量 366.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.46 mL 27.29 mL 54.58 mL
2.5 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
25 mM 0.11 mL 0.55 mL 1.09 mL

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产品说明书 for GW 2580

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for GW 2580

参考文献是支持产品生物活性的出版物。

Conway et al (2005) Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 102 16078 PMID: 16249345

Conway et al (2008) Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 326 41 PMID: 18434589

If you know of a relevant reference for GW 2580, please let us know.

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关键词: GW 2580, GW 2580 supplier, GW2580, cFMS, kinase, inhibitors, inhibits, CSF-1, colony-stimulating, factor, osteoclasts, arthritis, selective, orally, bioavailable, Other, RTKs, 5673, Tocris Bioscience

1 篇 GW 2580 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GW 2580 的部分引用包括：

Seung-Jae et al (2018) Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization. Immunity 49 275-287.e5 PMID: 30054206

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