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Submit ReviewGW 441756
说明： Potent, selective TrkA inhibitor
化学名： 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
纯度： ≥99% (HPLC)
生物活性 for GW 441756
GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline.
技术数据 for GW 441756
| 分子量 | 275.31 |
| 公式 | C17H13N3O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 504433-23-2 |
| PubChem ID | 16219401 |
| InChI Key | NXNQLECPAXXYTR-UHFFFAOYSA-N |
| Smiles | CN1C=C(C=C2C(=O)NC3=CC=CN=C23)C2=C1C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GW 441756
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 4.13 | 15 |
制备储备液 for GW 441756
以下数据基于产品分子量 275.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.15 mM | 24.22 mL | 121.08 mL | 242.15 mL |
| 0.75 mM | 4.84 mL | 24.22 mL | 48.43 mL |
| 1.5 mM | 2.42 mL | 12.11 mL | 24.22 mL |
| 7.5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
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产品说明书 for GW 441756
参考文献 for GW 441756
参考文献是支持产品生物活性的出版物。
Wood et al (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 14 953 PMID: 15013000
If you know of a relevant reference for GW 441756, please let us know.
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关键词: GW 441756, GW 441756 supplier, Potent, selective, TrkA, inhibitors, inhibits, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, GW441756, GlaxoSmithKline, GSK, Trk, 2238, Tocris Bioscience
5 篇 GW 441756 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GW 441756 的部分引用包括：
Lawn et al (2015) Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. Nat Chem Biol 290 3814 PMID: 25538243
Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Oncotarget 12 109 PMID: 26656090
Donatien et al (2018) Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization. Pain Rep 3 e676 PMID: 30534627
Edwards et al (2011) Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst 103 1162 PMID: 21771732
Wang et al (2008) Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases. Curr Chem Genomics 1 27 PMID: 20161825
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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