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Submit ReviewGW 627368
说明： Selective EP4 receptor competitive antagonist
化学名： 4-(4-,9-Diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)benzeneacetamide
纯度： ≥98% (HPLC)
生物活性 for GW 627368
GW 627368 is a selective prostanoid EP4 receptor competitive antagonist with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays). Affinity for all other prostanoid receptors is < 5.3. Inhibits U-46619 induced human platelet aggregation.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline.
技术数据 for GW 627368
| 分子量 | 544.62 |
| 公式 | C30H28N2O6S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 439288-66-1 |
| PubChem ID | 5312130 |
| InChI Key | XREWXJVMYAXCJV-UHFFFAOYSA-N |
| Smiles | O=C(NS(C5=CC=CC=C5)(=O)=O)CC(C=C4)=CC=C4N3CC2=C(OCC)C1=CC=CC=C1C(OCC)=C2C3=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GW 627368
参考文献 for GW 627368
参考文献是支持产品生物活性的出版物。
Wilson et al (2006) GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br.J.Pharmacol. 148 326 PMID: 16604093
Jones and Chan et al (2005) Investigation of the agonist activity of prostacyclin analogues on prostanoid EP4 receptors using GW 627368 and taprostene: evidence for species differences. Prostaglandins Leukot.Essent.Fatty.Acids. 72 289 PMID: 15763441
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关键词: GW 627368, GW 627368 supplier, GW627368, Prostanoid, receptors, EP4, TP, competitive, antagonists, platelet, aggregation, Receptors, 4668, Tocris Bioscience
1 篇 GW 627368 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GW 627368 的部分引用包括：
Edén et al (2015) Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated Ins secretion from human pancreatic islets. Diabetologia 58 2563 PMID: 26271343
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