GW 803430

Pricing Availability   Qty
说明: MCH1 antagonist
化学名: 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
纯度: ≥95% (HPLC)
说明书
引用文献
评论
文献 (2)

生物活性 for GW 803430

GW 803430 is a selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for GW 803430

分子量 481.99
公式 C25H24ClN3O3S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 515141-51-2
PubChem ID 9826520
InChI Key MWULMTACIBZPGN-UHFFFAOYSA-N
Smiles ClC(C=C3)=CC=C3C(S2)=CC1=C2C(N(C4=CC(OC)=C(OCCN5CCCC5)C=C4)C=N1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GW 803430

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 14.75 25

制备储备液 for GW 803430

以下数据基于产品分子量 481.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 8.3 mL 41.49 mL 82.99 mL
1.25 mM 1.66 mL 8.3 mL 16.6 mL
2.5 mM 0.83 mL 4.15 mL 8.3 mL
12.5 mM 0.17 mL 0.83 mL 1.66 mL

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参考文献 for GW 803430

参考文献是支持产品生物活性的出版物。

Rivera et al (2008) Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr.Med.Chem. 15 1025 PMID: 18393860

Gehlert et al (2009) Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J.Pharmacol.Exp.Ther. 329 429 PMID: 19182070


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关键词: GW 803430, GW 803430 supplier, glaxosmithkline, melanin, concentrating, hormone, receptors, mchr1, antagonists, antiobesity, obese, GW803430, Melanin-concentrating, Hormone, Receptors, 4242, Tocris Bioscience

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*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


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Depression Poster

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