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Submit ReviewGW 803430 is a selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.
Sold for research purposes under agreement from GlaxoSmithKline.
分子量 | 481.99 |
公式 | C25H24ClN3O3S |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 515141-51-2 |
PubChem ID | 9826520 |
InChI Key | MWULMTACIBZPGN-UHFFFAOYSA-N |
Smiles | ClC(C=C3)=CC=C3C(S2)=CC1=C2C(N(C4=CC(OC)=C(OCCN5CCCC5)C=C4)C=N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
1eq. HCl | 14.75 | 25 |
以下数据基于产品分子量 481.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.25 mM | 8.3 mL | 41.49 mL | 82.99 mL |
1.25 mM | 1.66 mL | 8.3 mL | 16.6 mL |
2.5 mM | 0.83 mL | 4.15 mL | 8.3 mL |
12.5 mM | 0.17 mL | 0.83 mL | 1.66 mL |
参考文献是支持产品生物活性的出版物。
Rivera et al (2008) Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr.Med.Chem. 15 1025 PMID: 18393860
Gehlert et al (2009) Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J.Pharmacol.Exp.Ther. 329 429 PMID: 19182070
If you know of a relevant reference for GW 803430, please let us know.
关键词: GW 803430, GW 803430 supplier, glaxosmithkline, melanin, concentrating, hormone, receptors, mchr1, antagonists, antiobesity, obese, GW803430, Melanin-concentrating, Hormone, Receptors, 4242, Tocris Bioscience
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
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