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说明： PARP14 inhibitor; cell-permeable
化学名： 3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid
纯度： ≥98% (HPLC)
生物活性 for H10
H10 is a PARP14 inhibitor (IC50 = 490 nM). Exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Binds both the nicotinamide and adenine sites on PARP14. Inhibits PARP14 and induces apoptosis in HepG2 and RPMI-8226 in cancer cells in vitro.
技术数据 for H10
| 分子量 | 557.58 |
| 公式 | C24H27N7O7S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2084811-68-5 |
| PubChem ID | 122707115 |
| InChI Key | MUOMSHSMJCWQFH-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=CC(NC(CCC(NCCC2=CN(N=N2)CCNS(=O)(C3=CC(C(O)=O)=CC=C3)=O)=O)=O)=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for H10
参考文献 for H10
参考文献是支持产品生物活性的出版物。
Peng et al (2017) Small molecule microarray based discovery of PARP14 inhibitors. Angew.Chem.Int.Ed.Engl. 56 248 PMID: 27918638
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关键词: H10, H10 supplier, PARP14, inhibitors, inhibits, apoptosis, Poly(ADP-ribose), Polymerase, 6228, Tocris Bioscience
1 篇 H10 的引用文献
引用文献是使用了 Tocris 产品的出版物。 H10 的部分引用包括：
George-Lucian et al (2022) The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1. Nat Commun 13 5063 PMID: 36030235
H10 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.