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HA 130

Cat. No. 4196 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective autotaxin inhibitor
化学名： B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HA 130

HA 130 is a potent and selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.

化合物库 for HA 130

HA 130 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for HA 130

分子量 463.29
公式 C24H19BFNO5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1229652-21-4
PubChem ID 46911532
InChI Key VTNKMYWFWQTEHE-XKZIYDEJSA-N
Smiles FC1=CC=C(CN3C(/C(SC3=O)=C/C2=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HA 130

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.33 100

制备储备液 for HA 130

以下数据基于产品分子量 463.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

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Dilution Calculator

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参考文献 for HA 130

参考文献是支持产品生物活性的出版物。

Albers et al (2010) Discovery and optimization of boronic acid based inhibitors of autotaxin. J.Med.Chem. 53 4958 PMID: 20536182

Albers et al (2010) Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc.Natl.Acad.Sci.USA 107 7257 PMID: 20360563

If you know of a relevant reference for HA 130, please let us know.

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关键词: HA 130, HA 130 supplier, HA130, autotaxin, inhibitors, reversible, reversibly, inhibits, selective, atx, npp2, lysophospholipases, d, lysopld, Autotaxin, 4196, Tocris Bioscience

2 篇 HA 130 的引用文献

引用文献是使用了 Tocris 产品的出版物。 HA 130 的部分引用包括：

Sandeep et al (2012) Exocrine pancreatic carcinogenesis and autotaxin expression. PLoS One 7 e43209 PMID: 22952646

Wheeler et al (2015) The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. J Neurosci 35 11399 PMID: 26269646

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