Haloperidol hydrochloride

Pricing Availability   Qty
说明: Dopamine antagonist; displays some D2 selectivity
化学名: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (9)
评论 (1)
文献 (2)

生物活性 for Haloperidol hydrochloride

Haloperidol hydrochloride is a dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

技术数据 for Haloperidol hydrochloride

分子量 412.33
公式 C21H23ClFNO2.HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1511-16-6
PubChem ID 11495267
InChI Key JMRYYMBDXNZQMH-UHFFFAOYSA-N
Smiles Cl.OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Haloperidol hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.31 25 温和加热

制备储备液 for Haloperidol hydrochloride

以下数据基于产品分子量 412.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 9.7 mL 48.5 mL 97.01 mL
1.25 mM 1.94 mL 9.7 mL 19.4 mL
2.5 mM 0.97 mL 4.85 mL 9.7 mL
12.5 mM 0.19 mL 0.97 mL 1.94 mL

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产品说明书 for Haloperidol hydrochloride

分析证书/产品说明书
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参考文献 for Haloperidol hydrochloride

参考文献是支持产品生物活性的出版物。

Beresford and Ward (1987) Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs 33 31 PMID: 3545764

IIyin et al (1996) Subtype-selective inhibition of N-MthD.-aspartate receptors by halope. Mol.Pharmacol. 50 1541 PMID: 8967976

Lynch and Gallagher (1996) Inhibition of N-MthD.-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors. J.Pharmacol.Exp.Ther. 279 154 PMID: 8858988

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Merck Index 12 4629

Gordon et al (2020) A SARS-CoV-2 protein-protein interaction map reveals drug targets and drug repurposing. Nature 583 459 PMID: 32353859


If you know of a relevant reference for Haloperidol hydrochloride, please let us know.

按产品操作查看相关产品

查看全部 Non-selective Dopamine Antagonists

关键词: Haloperidol hydrochloride, Haloperidol hydrochloride supplier, Antagonists, partly, D2-like, selective, High, affinity, ligands, σ1, sigma1, σ2, sigma2, antagonist, Dopamine, Non-Selective, Receptors, dopaminergic, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Non-selective, Sigma1, 0931, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Haloperidol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

9 篇 Haloperidol hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Haloperidol hydrochloride 的部分引用包括:

Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177 PMID: 22925888

Watson et al (2012) The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. Neuropsychopharmacology 1436 111 PMID: 22200378

Balu et al (2008) Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res 1211 37 PMID: 18433734

Joshi and Panicker (2019) Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs. Eneuro 5 PMID: 30713996


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Antagonist of D2R.
By Luiz Alexandre Magno on 10/26/2018
分析类型: In Vitro
种属: Rat
细胞系/组织: PC12 cells

I used haloperidol hydrochloride to block D2 dopamine receptors, which increases phosphorylation of the Akt protein (see the western blot image).

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该领域的文献

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*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.