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说明： Putative endogenous imidazoline ligand. Also MAO inhibitor
别名： Harman
化学名： 1-Methyl-9H-pyrido[3,4-b]indole
纯度： ≥99% (HPLC)
生物活性 for Harmane
Harmane is a proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).
技术数据 for Harmane
| 分子量 | 182.22 |
| 公式 | C12H10N2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 486-84-0 |
| PubChem ID | 5281404 |
| InChI Key | PSFDQSOCUJVVGF-UHFFFAOYSA-N |
| Smiles | CC1=NC=CC2=C1NC1=C2C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Harmane
参考文献 for Harmane
参考文献是支持产品生物活性的出版物。
Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35 PMID: 10415895
Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209 PMID: 7130973
Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057 PMID: 10725251
Hudson et al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 126 2P
Merck Index 12 4646
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关键词: Harmane, Harmane supplier, MAO-A, MAO-B, inhibitors, inhibits, putative, endogenous, imidazolines, ligand, MAO, monoamine, oxygenases, oxidases, I1, I2, Harman, General, Imidazolines, Monoamine, Oxidase, Adrenergic, Related, Compounds, Dopaminergic-Related, 5-HT-Related, 5-HT3, Receptors, 1132, Tocris Bioscience
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