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说明： Fluorescent TG2/LRP1 substrate for imaging endocytosis

纯度： ≥90% (HPLC)

说明书

引用文献

生物活性 Scientific Data 技术数据溶解性计算器说明书参考文献

生物活性 for HB-2-30

Key information: HB-2-30 is a far-red fluorescent transglutaminase-2 (TG2) probe for imaging endocytosis in vitro and in vivo. HB-2-30 undergoes highly efficient endocytosis in complex with TG2 and α2-macroglobulin via the LRP1 pathway.

Application: Confocal microscopy.

Properties and Photophysical Data: Suitable for multiplexing and can be combined with DAPI (Cat. No. 5748) counter-staining. Excitation and emission maxima (λ) are 649 and 665 nm, respectively.

Scientific Data

Confocal Microscopy

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Application of HB-2-30 in vitro. Confocal microscopy images of bone marrow-derived dendritic cells from WT C57BL/6 mice (left) and TG2KO mice (right) incubated with 3μM HB-2-30. Cells were incubated for 90 minutes with the probe before being fixed, stained for nuclei (blue), and imaged. HB-2-30 signals is in red.

Confocal Microscopy

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Application of HB-2-30 in vivo. Ileum tissue sections from mice dosed with 10 mg/kg HB-2-30. WT C57BL/6 mice (left) and TG2KO mice (right) were dosed with HB-2-30 and sacrificed after 2 hours. Intestines were Swiss rolled, thin sectioned, stained for nuclei (blue), and imaged via confocal fluorescence microscopy. HB-2-30 signal is in red.

许可信息

Sold under license from Stanford University

Optical Data for HB-2-30

λ_abs	649 nm
λ_em	665 nm
Application	Confocal microscopy

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectral Viewer

技术数据 for HB-2-30

分子量	1307.59
公式	C₆₆H₈₆N₁₀O₁₄S₂
序列	PXXPF (Modifications: Pro-1 = N-terminal Ac, X-2 = (S,E)-2-amino-7-(dimethylamino)-7-oxohept-5-enoic acid, X-3 = Dab(Sulfo-Cy5), Phe-5 = C-terminal amide)
储存	Store at -20°C
纯度	≥90% (HPLC)
CAS Number	3031522-14-9
InChI Key	ILCHGSXJNAIGGG-AFAVFPMXSA-N
Smiles	O=C(N1[C@@H](CCC1)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)[C@@H](NC([C@H](CC/C=C/C(N(C)C)=O)NC([C@H]3N(CCC3)C(C)=O)=O)=O)CCNC(CCCCC[N+]4=C(/C=C/C=C/C=C5C(C)(C6=CC(S(=O)(O)=O)=CC=C6N\5C)C)C(C)(C)C7=CC(S(=O)([O-])=O)=CC=C47)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HB-2-30

溶解性	Soluble to 13.08 mg/ml in DMSO

产品说明书 for HB-2-30

分析证书/产品说明书

化学品安全技术说明书

参考文献 for HB-2-30

参考文献是支持产品生物活性的出版物。

Loppinet et al (2023) LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens. Cell Chem.Biol. 30 PMID: 36608691

Loppinet et al (2023) Targeted lysosomal degradation of secreted and cell surface proteins through the LRP-1 pathway. J.Am.Chem.Soc. 145 18705 PMID: 37590164

If you know of a relevant reference for HB-2-30, please let us know.

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关键词: HB-2-30, HB-2-30 supplier, Hb230, fluorescent, probe, probes, TG2, LRP1, α2-macroglobulin, endocytosis, LYTAC, lysosome, targeting, chimera, lysosomal, in, vivo, Fluorescent, Lysosome, Probes, 8831, Tocris Bioscience

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