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HDAC4 CHDI Degrader 11

Cat. No. 7882 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective HDAC4 Degrader (PROTAC®)
化学名： (2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HDAC4 CHDI Degrader 11

HDAC4 CHDI Degrader 11 is a potent and selective HDAC4 Degrader (PROTAC®) (DC50 values are 4 and 6 nM in Jurkat E6-1 and Jurkat cells respectively). Comprises the class IIa HDAC inhibitor trifluoromethyloxadiazole joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. In a mouse cell model of Huntington's disease, HDAC4 CHDI Degrader 11 potently degrades HDAC4 (DC50 = 1nM). Can be used with P-glycoprotein inhibitor Elacridar (Cat. No. 4646) for more effective degradation in neuroblastoma cell lines.

HDAC4 antibody validated for Simple Western™ (automated Western) instruments also available: Catalog # NBP2-22151.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

技术数据 for HDAC4 CHDI Degrader 11

分子量 1075.26
公式 C52H73F3N8O11S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3035189-46-6
InChI Key KBDZFZJFGKYVBZ-KLSSUPLUSA-N
Smiles O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(COCCOCCOCCOCCOCCCCN(C[C@H](NC(C4=CC=C(C=C4)C5=NOC(C(F)(F)F)=N5)=O)C)CCC)=O)C(C)(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HDAC4 CHDI Degrader 11

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 53.76 50

制备储备液 for HDAC4 CHDI Degrader 11

以下数据基于产品分子量 1075.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 1.86 mL 9.3 mL 18.6 mL
2.5 mM 0.37 mL 1.86 mL 3.72 mL
5 mM 0.19 mL 0.93 mL 1.86 mL
25 mM 0.04 mL 0.19 mL 0.37 mL

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产品说明书 for HDAC4 CHDI Degrader 11

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for HDAC4 CHDI Degrader 11

参考文献是支持产品生物活性的出版物。

Macabuag et al (2022) Developing HDAC4-selective protein degraders to investigate the role of HDAC4 in Huntington's disease pathology. J.Med.Chem. 6512445 PMID: 36098485

If you know of a relevant reference for HDAC4 CHDI Degrader 11, please let us know.

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