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说明： Potent inhibitor of the ErbB receptor family
化学名： N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide
纯度： ≥97% (HPLC)
生物活性 for HDS 029
Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).
技术数据 for HDS 029
| 分子量 | 355.76 |
| 公式 | C17H11ClFN5O |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 881001-19-0 |
| PubChem ID | 11566580 |
| InChI Key | DLPSDPPZXRJQOY-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=C(Cl)C=C3NC1=NC=NC2=C1C=C(NC(C#CC)=O)N=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for HDS 029
参考文献 for HDS 029
参考文献是支持产品生物活性的出版物。
Klutchko et al (2006) Tyrosine kinase inhibitors. 19. 6-alkynamides of 4-anilinoquinazolines and 4-aniliopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J.Med.Chem. 49 1475 PMID: 16480284
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关键词: HDS 029, HDS 029 supplier, Potent, inhibitors, inhibits, ErbB, receptor, family, Epidermal, Growth, Factors, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, HDS029, 2646, Tocris Bioscience
1 篇 HDS 029 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HDS 029 的部分引用包括：
Watanabe et al (2011) A novel glycosylation signal regulates transforming growth factor beta receptors as evidenced by endo-beta-galactosidase C expression in rodent cells. Glycobiology 21 482 PMID: 21062784
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