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HEMTAC 26

Cat. No. 7940 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader
化学名： 4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazineacetamide
纯度： ≥95% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HEMTAC 26

HEMTAC 26 is a potent HSP90-mediated targeting chimera (HEMTAC) that degrades CDK6 and CDK4 (DC50 values are 19 nM and 26 nM; Dmax = 92% and 88% in B16F10 cells, 36h treatment). HEMTAC 26 inhibits growth of a range of cancer cell lines including B16F10 and A375 (IC50 values are 112 nM and 126 nM respectively). Induces cell cycle arrest at G0/G1 phase in B16F10 cells.

技术数据 for HEMTAC 26

分子量 953.51
公式 C48H53ClN16O4
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2821803-61-4
PubChem ID 167312304
InChI Key VSAXVERDPZMCPX-UHFFFAOYSA-N
Smiles O=C1C(C(C)=O)=C(C)C2=C(N1C3CCCC3)N=C(NC4=NC=C(N5CCN(CC5)CC(NCC6=CN(CCC#CC7=CN(CC8=NC=C(C)C(OC)=C8C)C9=C7C(Cl)=NC(N)=N9)N=N6)=O)C=C4)N=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HEMTAC 26

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 95.35 100

制备储备液 for HEMTAC 26

以下数据基于产品分子量 953.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.24 mL 10.49 mL
5 mM 0.21 mL 1.05 mL 2.1 mL
10 mM 0.1 mL 0.52 mL 1.05 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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参考文献 for HEMTAC 26

参考文献是支持产品生物活性的出版物。

Li et al (2023) Targeted protein degradation induced by HEMTACs based on HSP90. J.Med.Chem. 66 733 PMID: 36574496

If you know of a relevant reference for HEMTAC 26, please let us know.

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia