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Hh-Ag1.5

Cat. No. 7807 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and high affinity Smo receptor agonist
化学名： 3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Hh-Ag1.5

Hh-Ag1.5 is a potent and high affinity Smoothened (Smo) receptor agonist (EC50 = 1 nM; Ki values are 0.5 and 2.3 nM respectively, in a [3H]SAG-1.3 and [3H]Cyclopamine binding assay). It is used in protocols for the chemical reprogramming of mouse embryonic fibroblasts into neural stem cells. Also induces differentiation of hiPSCs into skin-derived precursor cells, spinal motor neurons and spinal sensory neurons.

技术数据 for Hh-Ag1.5

分子量 526.04
公式 C28H26ClF2N3OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 612542-14-0
PubChem ID 44195701
InChI Key HRUSRVLDSXRNFP-UPDYAAQLSA-N
Smiles O=C(N(CC1=CC(C2=CC=NC=C2)=CC=C1)[C@H]3CC[C@H](NC)CC3)C(SC4=C(C=CC(F)=C54)F)=C5Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Hh-Ag1.5

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.6 100
ethanol 26.3 50

制备储备液 for Hh-Ag1.5

以下数据基于产品分子量 526.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.5 mL 19.01 mL
5 mM 0.38 mL 1.9 mL 3.8 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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参考文献 for Hh-Ag1.5

参考文献是支持产品生物活性的出版物。

Frank-Kamenetsky et al (2002) Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J.Biol. 1 10 PMID: 12437772

Rominger et al (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J.Pharmacol.Exp.Ther. 329 995 PMID: 19304771

Takeda et al (2018) Chemical compound-based direct reprogramming for future clinical applications. Biosci.Rep. 38 BSR20171650 PMID: 29739872

Sugiyama-Nakagiri et al (2016) Induction of skin-derived precursor cells from human induced pluripotent stem cells. PLoS One 11 e0168451 PMID: 27992514

If you know of a relevant reference for Hh-Ag1.5, please let us know.

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

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