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Submit ReviewHistamine dihydrochloride
说明： Endogenous histamine receptor agonist
化学名： 2-(4-Imidazolyl)ethylamine dihydrochloride
生物活性 for Histamine dihydrochloride
Histamine dihydrochloride is an endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.
化合物库 for Histamine dihydrochloride
Histamine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Histamine dihydrochloride
| 分子量 | 184.07 |
| 公式 | C5H9N3.2HCl |
| 储存 | Desiccate at RT |
| CAS Number | 56-92-8 |
| PubChem ID | 5818 |
| InChI Key | PPZMYIBUHIPZOS-UHFFFAOYSA-N |
| Smiles | NCCC1=CNC=N1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Histamine dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 18.41 | 100 | |
| DMSO | 18.41 | 100 |
制备储备液 for Histamine dihydrochloride
以下数据基于产品分子量 184.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.43 mL | 27.16 mL | 54.33 mL |
| 5 mM | 1.09 mL | 5.43 mL | 10.87 mL |
| 10 mM | 0.54 mL | 2.72 mL | 5.43 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.09 mL |
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产品说明书 for Histamine dihydrochloride
参考文献 for Histamine dihydrochloride
参考文献是支持产品生物活性的出版物。
Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253 PMID: 9311023
Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41 PMID: 18172439
Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185 PMID: 17490952
If you know of a relevant reference for Histamine dihydrochloride, please let us know.
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关键词: Histamine dihydrochloride, Histamine dihydrochloride supplier, Endogenous, histamine, receptor, agonists, H4, Receptors, Histamine, H1, H2, H3, histaminergic, 3545, Tocris Bioscience
9 篇 Histamine dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Histamine dihydrochloride 的部分引用包括：
Vincenzo et al (2021) 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors. Mol Brain 14 28 PMID: 33557888
Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Acta Pharmacol Sin 303 C467 PMID: 22700794
David E et al (2022) A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell 185 3390-3407.e18 PMID: 36055200
JoAnn et al (2019) G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem 294 5867-5878 PMID: 30760523
Hao et al (2019) A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron 102 745-761.e8 PMID: 30922875
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
Chen et al (2017) Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell 21 747 PMID: 29198940
Femenia et al (2015) Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol 18 PMID: 25762718
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
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Histamine dihydrochloride 的评论
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Histamine releases Ca2+ from ER stores in EA.hy926 cells..
By
Niroj Shrestha on 12/04/2018
分析类型： In Vitro
种属： Human
细胞系/组织： EA.hy926
EA.hy926 cells were loaded with cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM histamine in 0.1 mM EGTA-tyrode solution, resulting in transient cytosolic Ca2+ peak.
该领域的文献
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Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.