主页 / 药理学 / Enzymes / GTPases / Small Monomeric GTPases / EPAC / EPAC Inhibitors / HJC 0350

HJC 0350

Cat. No. 4844 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective Epac2 inhibitor
化学名： 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HJC 0350

HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.

化合物库 for HJC 0350

HJC 0350 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for HJC 0350

分子量 277.38
公式 C15H19NO2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 885434-70-8
PubChem ID 22200891
InChI Key AFZWZVLPIMHLSE-UHFFFAOYSA-N
Smiles CC1=CC(C)=C(S(N2C(C)=CC(C)=C2)(=O)=O)C(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HJC 0350

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 13.87 50
ethanol 5.55 20

制备储备液 for HJC 0350

以下数据基于产品分子量 277.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 7.21 mL 36.05 mL 72.1 mL
2.5 mM 1.44 mL 7.21 mL 14.42 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
25 mM 0.14 mL 0.72 mL 1.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for HJC 0350

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for HJC 0350

参考文献是支持产品生物活性的出版物。

Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952 PMID: 23286832

If you know of a relevant reference for HJC 0350, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 EPAC Inhibitors

关键词: HJC 0350, HJC 0350 supplier, HJC0350, EPAC, EPAC2, epacs, antagonists, inhibitors, inhibits, exchange, proteins, directly, activated, by, cAMP, Rap, guanine, nucleotide, factor, 4, RAPGEF4, GEFI, 4844, Tocris Bioscience

2 篇 HJC 0350 的引用文献

引用文献是使用了 Tocris 产品的出版物。 HJC 0350 的部分引用包括：

Derek C et al (2021) Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci 41 2883-2898 PMID: 33593853

Cheng-Mao et al (2018) The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem 293 717-730 PMID: 29158262

您是否知道使用了 Tocris HJC 0350 的优秀论文？ 请告知我们.

HJC 0350 的评论

目前没有该产品的评论。 Be the first to review HJC 0350 and earn rewards!

Have you used HJC 0350?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review