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Submit ReviewHNGF6A
Discontinued Product
5154 has been discontinued.
View all Insulin and Insulin-like Receptors products.
说明： Humanin analog; increases insulin sensitivity
生物活性 for HNGF6A
HNGF6A is a humanin analog; increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. Also enhances glucose sensing in βTC3 cells and lowers blood glucose in Zucker diabetic fatty rats. Prevents endothelial dysfunction and delays progression of atherosclerosis in vivo. Protects neurons from NMDA-induced toxicity.
技术数据 for HNGF6A
| 分子量 | 2581.13 |
| 公式 | C112H198N34O31S2 |
| 序列 | MAPRGASCLLLLTGEIDLPVKRRA |
| 储存 | Store at -20°C |
| CAS Number | 1093111-54-6 |
| PubChem ID | 90489015 |
| InChI Key | OQIJKOVTOUEJGW-VFDWMCQBSA-N |
| Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for HNGF6A
参考文献 for HNGF6A
参考文献是支持产品生物活性的出版物。
Kuliawat et al (2013) Potent humanin analog increases glucose-stimulated Ins secretion through enhanced metabolism in the β cell. FASEB J. 27 4890 PMID: 23995290
Muzumdar et al (2009) Humanin: a novel central regulator of peripheral Ins action. PLoS One. 4 e6334 PMID: 19623253
Oh et al (2011) Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 219 65 PMID: 21763658
Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 9 462 PMID: 29161500
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关键词: HNGF6A, HNGF6A supplier, Alzheimer's, disease, insulin, diabetes, β, cells, humanin, endothelial, dysfunction, atherosclerosis, analogue, HN, beta, analog, Insulin, and, Insulin-like, Receptors, insulin-like, 5154, Tocris Bioscience
1 篇 HNGF6A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HNGF6A 的部分引用包括：
Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 9 462 PMID: 29161500
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for HNGF6A
