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HOE 140

Cat. No. 3014 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective B2 antagonist
别名： Icatibant
纯度： ≥95% (HPLC)
说明书
引用文献 (5)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HOE 140

HOE 140 is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).

技术数据 for HOE 140

分子量 1304.52
公式 C59H89N19O13S
序列 RRPXGXSXXR

(Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = D-Tic, X-9 = Oic)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 130308-48-4
PubChem ID 90488794
InChI Key QURWXBZNHXJZBE-JNFYKTHFSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1C3CCCCC3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HOE 140

溶解性 Soluble to 1 mg/ml in water

产品说明书 for HOE 140

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for HOE 140

参考文献是支持产品生物活性的出版物。

Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851

Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683 PMID: 8075888

Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984

If you know of a relevant reference for HOE 140, please let us know.

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关键词: HOE 140, HOE 140 supplier, Potent, selective, B2, antagonists, Receptors, Bradykinin, HOE140, Icatibant, 3014, Tocris Bioscience

5 篇 HOE 140 的引用文献

引用文献是使用了 Tocris 产品的出版物。 HOE 140 的部分引用包括：

Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324

Zhou et al (2019) Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2. Int J Oncol 55 131 PMID: 31059006

Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088

Xu et al (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol 51 370 PMID: 24669857

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HOE 140 的评论

平均评分: 4 (Based on 1 Review.)

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works good.
By Anonymous on 05/13/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： neurons

B2 receptor blocker HOE140, 200 nM

treat 20 min

PMID: 28951324 参考文献
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