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HQL 79

Cat. No. 3530 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
化学名： 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HQL 79

HQL 79 is an orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.

化合物库 for HQL 79

HQL 79 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for HQL 79

分子量 377.48
公式 C22H27N5O
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 162641-16-9
PubChem ID 6540277
InChI Key TZQGXAHOROZEKN-UHFFFAOYSA-N
Smiles C1(CCCN2CCC(OC(C4=CC=CC=C4)C3=CC=CC=C3)CC2)=NN=NN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HQL 79

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.44 25

制备储备液 for HQL 79

以下数据基于产品分子量 377.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 10.6 mL 52.98 mL 105.97 mL
1.25 mM 2.12 mL 10.6 mL 21.19 mL
2.5 mM 1.06 mL 5.3 mL 10.6 mL
12.5 mM 0.21 mL 1.06 mL 2.12 mL

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参考文献 for HQL 79

参考文献是支持产品生物活性的出版物。

Aritake et al (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 281 15277 PMID: 16547010

Matsushita et al (1998) Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 78 11 PMID: 9804057

Mohri et al (2006) Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 26 4383 PMID: 16624958

If you know of a relevant reference for HQL 79, please let us know.

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关键词: HQL 79, HQL 79 supplier, HQL79, specific, hematopoietic, prostaglandin, D, synthase, HPGDS, inhibitors, inhibits, antiallergic, anti-inflammatory, Other, Synthases/Synthetases, 3530, Tocris Bioscience

2 篇 HQL 79 的引用文献

引用文献是使用了 Tocris 产品的出版物。 HQL 79 的部分引用包括：

Yu et al (2017) Prostaglandin D2 Regulates SOX9 Nuclear Translocation during Gonadal Sex Determination in Tammar Wallaby, Macropus eugenii. Sex Dev 11 143-150 PMID: 28472794

Song et al (2018) Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice. J Pharmacol Exp Ther 367 425 PMID: 30305427

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