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Submit ReviewHS 014
说明： Selective MC4 receptor antagonist
纯度： ≥95% (HPLC)
生物活性 for HS 014
HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.
技术数据 for HS 014
| 分子量 | 1563.77 |
| 公式 | C71H94N20O17S2 |
| 序列 |
CEHXRWGCPPKD (Modifications: Cys-1 = N-terminal Ac, X = D-2-Nal, Asp-12 = C-terminal amide, Disulfide bridge: 1-8) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 207678-81-7 |
| PubChem ID | 24821295 |
| InChI Key | BRGDPINZISNYJL-VMAVSDBDSA-N |
| Smiles | CC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for HS 014
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for HS 014
参考文献 for HS 014
参考文献是支持产品生物活性的出版物。
Bellasio et al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID: 14660013
Schioth et al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75 PMID: 9630346
Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 54 509 PMID: 18082228
If you know of a relevant reference for HS 014, please let us know.
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关键词: HS 014, HS 014 supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, HS014, 1831, Tocris Bioscience
1 篇 HS 014 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HS 014 的部分引用包括：
Panaro et al (2014) The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. PLoS One 20 1018 PMID: 25453189
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.