Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewHS 024
说明： Highly potent MC4 receptor antagonist
纯度： ≥95% (HPLC)
生物活性 for HS 024
HS 024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
技术数据 for HS 024
| 分子量 | 1266.5 |
| 公式 | C58H79N19O10S2 |
| 序列 |
CXRHXRWGC (Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge: 1-9) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 212370-59-7 |
| PubChem ID | 25081552 |
| InChI Key | PUOCNCOPVAOMDE-LQXMKOPKSA-N |
| Smiles | CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for HS 024
| 溶解性 | Soluble to 0.50 mg/ml in water |
产品说明书 for HS 024
参考文献 for HS 024
参考文献是支持产品生物活性的出版物。
Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703 PMID: 11726778
Jonsson et al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517 PMID: 12065241
Kask et al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 5006 PMID: 9832440
If you know of a relevant reference for HS 024, please let us know.
按产品操作查看相关产品
关键词: HS 024, HS 024 supplier, potent, MC4R, receptor, antagonists, Receptors, Melanocortin, HS024, 1832, Tocris Bioscience
2 篇 HS 024 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HS 024 的部分引用包括：
Simamura et al (2015) Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. J Neurochem 10 e0123232 PMID: 25860801
Nepomuceno et al (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol 9 157 PMID: 29599718
您是否知道使用了 Tocris HS 024 的优秀论文？ 请告知我们.
HS 024 的评论
目前没有该产品的评论。 Be the first to review HS 024 and earn rewards!
Have you used HS 024?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.