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Submit ReviewHU 308
说明： Potent and selective CB2 agonist
化学名： (1S,4S,5S)-4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
纯度： ≥98% (HPLC)
生物活性 for HU 308
HU 308 is a potent and selective CB2 receptor agonist (Ki values are 22.7 nM and > 10 μM for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.
技术数据 for HU 308
| 分子量 | 414.62 |
| 公式 | C27H42O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 256934-39-1 |
| PubChem ID | 11553430 |
| InChI Key | CFMRIVODIXTERW-BDTNDASRSA-N |
| Smiles | CCCCCCC(C)(C)C1=CC(OC)=C([C@]2([H])[C@H](C3)C(C)(C)[C@H]3C(CO)=C2)C(OC)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for HU 308
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.46 | 100 | |
| ethanol | 41.46 | 100 |
制备储备液 for HU 308
以下数据基于产品分子量 414.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.06 mL | 24.12 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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产品说明书 for HU 308
参考文献 for HU 308
参考文献是支持产品生物活性的出版物。
LaBuda et al (2005) Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur.J.Pharmacol. 527 172 PMID: 16316653
Hanus et al (1999) HU-308: a specific agonist for CB2, a peripheral cannabinoid receptor. Proc.Natl.Acad.Sci.USA 96 14228 PMID: 10588688
Palazuelos et al (2009) Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain 132 3152 PMID: 19805493
If you know of a relevant reference for HU 308, please let us know.
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关键词: HU 308, HU 308 supplier, Potent, selective, CB2, agonists, cannabinoids, Receptors, HU308, cb2r, huntingtons, disease, 3088, Tocris Bioscience
7 篇 HU 308 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HU 308 的部分引用包括：
Ke et al (2016) Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages PLoS One 11 e0155076 PMID: 27611972
Presley et al (2015) Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist. Brain Res 3 e00159 PMID: 26196013
Gianella-Borradori et al (2015) Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists. Bioorg Med Chem 23 241 PMID: 25487422
Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Pharmacol Res Perspect 2014 978678 PMID: 24803745
Solbrig et al (2013) Prospects for cannabinoid therapies in viral encephalitis. Proc Natl Acad Sci U S A 1537 273 PMID: 24021420
Sheng et al (2019) Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Pain Res Manag 2019 1260353 PMID: 31354896
Acevedo-Canabal et al (2019) Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2. Cannabis Cannabinoid Res 4 88 PMID: 31236475
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.