Ibutilide hemifumarate

Cat. No. 3908 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Blocks I_Kr, hERG and L-type Ca²⁺ channels; class III antiarrhythmic

化学名： (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ibutilide hemifumarate

Ibutilide hemifumarate is a class III antiarrhythmic. Blocks the rapid component of delayed rectifier K⁺ current (I_Kr); also blocks hERG channels and L-type Ca²⁺ channels. Shown to activate a slow inward Na⁺ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.

化合物库 for Ibutilide hemifumarate

Ibutilide hemifumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ibutilide hemifumarate

分子量	442.61
公式	C₂₀H₃₆N₂O₃S.½C₄H₄O₄
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	122647-32-9
PubChem ID	5281065
InChI Key	PCIOHQNIRPWFMV-WXXKFALUSA-N
Smiles	CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1.O=C(/C=C/C(O)=O)O.CCCCCCCN(CC)CCCC(O)C2=CC=C(NS(C)(=O)=O)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ibutilide hemifumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	44.26	100
	water	44.26	100

制备储备液 for Ibutilide hemifumarate

以下数据基于产品分子量 442.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.3 mL	22.59 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for Ibutilide hemifumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ibutilide hemifumarate

参考文献是支持产品生物活性的出版物。

Merck Index 12 4927

Murray (1998) Ibutilide. Circulation 97 493 PMID: 9490245

Perry et al (2004) Structural determinants of HERG channel block by clofilium and ibut. Mol.Pharmacol. 66 240 PMID: 15266014

Lee and Lee (1998) Ionic mechanism of ibut. in human atrium: evidence for a drug-induced Na⁺ current through nifed. inhibited inward channel. J.Pharmacol.Exp.Ther. 286 9 PMID: 9655836

If you know of a relevant reference for Ibutilide hemifumarate, please let us know.

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关键词: Ibutilide hemifumarate, Ibutilide hemifumarate supplier, antiarrhythmics, ion, channel, blockers, IKr, HERG, L-type, Ca2+, channels, atrial, fibrillation, flutter, Other, Channel, Modulators, 3908, Tocris Bioscience

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