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Submit ReviewICI 192,605
说明： Potent thromboxane A2/TP receptor antagonist
化学名： 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid
纯度： ≥98% (HPLC)
生物活性 for ICI 192,605
Potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619 (Cat. No. 1932).
许可信息
Sold with the permission of AstraZeneca UK Ltd.
技术数据 for ICI 192,605
| 分子量 | 402.87 |
| 公式 | C22H23ClO5 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 117621-64-4 |
| PubChem ID | 6604763 |
| InChI Key | WHUIENZXNGAHQI-GKZDNZBASA-N |
| Smiles | OC(=O)CC\C=C/C[C@@H]1CO[C@@H](O[C@@H]1C1=C(O)C=CC=C1)C1=C(Cl)C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ICI 192,605
参考文献 for ICI 192,605
参考文献是支持产品生物活性的出版物。
Arakawa et al (1993) Leukotriene D4 and prostaglandin F2a- induced airflow obstruction and airway plasma exudation in guinea pig: role of thromboxane and its receptor. Br.J.Pharmacol. 110 127 PMID: 8220872
Brewster et al (1988) The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid ICI 192605. Prostaglandins 36 173 PMID: 2973084
Cao et al (2004) Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity. Eur.J.Pharmacol. 485 317 PMID: 14757156
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关键词: ICI 192,605, ICI 192,605 supplier, Potent, thromboxane, A2, TXA2, TP, receptor, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI192605, AstraZeneca, Receptors, 0837, Tocris Bioscience
1 篇 ICI 192,605 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ICI 192,605 的部分引用包括：
Daray et al (2003) Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein. Naunyn Schmiedebergs Arch Pharmacol 139 1409 PMID: 12922927
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