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Submit ReviewICI 63197
说明： PDE4 inhibitor
化学名： 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
纯度： ≥99% (HPLC)
生物活性 for ICI 63197
Potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.
技术数据 for ICI 63197
| 分子量 | 207.23 |
| 公式 | C9H13N5O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 27277-00-5 |
| PubChem ID | 62824 |
| InChI Key | UQDVRVNMIJAGRK-UHFFFAOYSA-N |
| Smiles | CCCN1C2=NC(N)=NN2C=C(C)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ICI 63197
参考文献 for ICI 63197
参考文献是支持产品生物活性的出版物。
Kaulen et al (1989) Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram. Brain Res. 503 229 PMID: 2557965
Wachtel (1983) Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 22 267 PMID: 6302550
Zhao et al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram J.Pharmacol.Exp.Ther. 305 565 PMID: 12704225
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关键词: ICI 63197, ICI 63197 supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, ICI63197, 1816, Tocris Bioscience
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