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说明： Sustains self-renewal and pluripotency of ESCs
化学名： 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
纯度： ≥99% (HPLC)
生物活性 for ID 8
ID 8 is a sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period). Also supports human PSC maintenance in combiantions with Wnt3a. DYRK inhibitor
技术数据 for ID 8
| 分子量 | 298.29 |
| 公式 | C16H14N2O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 147591-46-6 |
| PubChem ID | 791637 |
| InChI Key | VVZNWYXIOADGSW-UHFFFAOYSA-N |
| Smiles | CC2=C([N+]([O-])=O)C1=CC=C(O)C=C1N2C3=CC=C(OC)C=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ID 8
参考文献 for ID 8
参考文献是支持产品生物活性的出版物。
Miyabayashi et al (2008) Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci.Biotechnol.Biochem. 72 1242 PMID: 18460821
Firestone and Chen (2009) Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem.Biol. 5 15
Hasegawa et al (2012) Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl.Med. 1 18 PMID: 23197636
关键词: ID 8, ID 8 supplier, Sustains, self-renewal, pluripotency, embryonic, stem, cells, ESCs, id8, id, 8, Stem, Cell, Proliferation, DYRK, 3853, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.