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IHR 1

Cat. No. 5554 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent Smo antagonist
化学名： N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for IHR 1

IHR 1 is a potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Fluorescent Analog also available.

技术数据 for IHR 1

分子量 454.13
公式 C20H12Cl4N2O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 548779-60-8
PubChem ID 2167042
InChI Key VCLHHRGZKNUOAQ-UHFFFAOYSA-N
Smiles ClC1=CC(C(NC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3)=O)C=C2)=O)=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IHR 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.08 20 温和加热

制备储备液 for IHR 1

以下数据基于产品分子量 454.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.01 mL 55.05 mL 110.1 mL
1 mM 2.2 mL 11.01 mL 22.02 mL
2 mM 1.1 mL 5.51 mL 11.01 mL
10 mM 0.22 mL 1.1 mL 2.2 mL

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参考文献 for IHR 1

参考文献是支持产品生物活性的出版物。

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239

If you know of a relevant reference for IHR 1, please let us know.

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关键词: IHR 1, IHR 1 supplier, IHR1, potent, smoothened, smo, antagonists, hedgehog, signaling, inhibitors, inhibits, response, receptors, Smoothened, Receptors, Hedgehog, Signaling, 5554, Tocris Bioscience

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