Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewIloprost
说明： Prostacyclin (PGI2) analog
别名： ZK 36374
化学名： (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid
纯度： ≥97% (HPLC)
生物活性 for Iloprost
Iloprost is a prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).
技术数据 for Iloprost
| 分子量 | 360.49 |
| 公式 | C22H32O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 78919-13-8 |
| PubChem ID | 5311181 |
| InChI Key | HIFJCPQKFCZDDL-ACWOEMLNSA-N |
| Smiles | O[C@@H]1C[C@H]2[C@H](C/C(C2)=C/CCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Iloprost
参考文献 for Iloprost
参考文献是支持产品生物活性的出版物。
Della Bella et al (2001) Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 65 73 PMID: 11403500
Abramovitz et al (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285 PMID: 10634944
Schror et al (1981) The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro. Naunyn-Schmied.Arch.Pharmacol. 316 252
按标靶查看相关产品
按产品操作查看相关产品
关键词: Iloprost, Iloprost supplier, Prostacyclin, PGI2, IP, EP1, EP3, Receptors, Prostaglandin, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ZK36374, ZK, 36374, 2038, Tocris Bioscience
2 篇 Iloprost 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Iloprost 的部分引用包括：
Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. Nat Commun 11 e1004118 PMID: 25723389
Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902
Iloprost 的评论
目前没有该产品的评论。 Be the first to review Iloprost and earn rewards!
Have you used Iloprost?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image