Imipramine hydrochloride

Cat. No. 7841 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment

化学名： 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Imipramine hydrochloride

Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (K_i values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.

化合物库 for Imipramine hydrochloride

Imipramine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Imipramine hydrochloride

分子量	316.87
公式	C₁₉H₂₄N₂.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	113-52-0
PubChem ID	8228
InChI Key	XZZXIYZZBJDEEP-UHFFFAOYSA-N
Smiles	CN(C)CCCN(C1=C(CC2)C=CC=C1)C3=C2C=CC=C3.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Imipramine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	15.84	50
	water	15.84	50

制备储备液 for Imipramine hydrochloride

以下数据基于产品分子量 316.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	6.31 mL	31.56 mL	63.12 mL
2.5 mM	1.26 mL	6.31 mL	12.62 mL
5 mM	0.63 mL	3.16 mL	6.31 mL
25 mM	0.13 mL	0.63 mL	1.26 mL

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产品说明书 for Imipramine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Imipramine hydrochloride

参考文献是支持产品生物活性的出版物。

Wang et al (2021) Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide. J.Cell.Mol.Med. 25 9350 PMID: 34469035

Chryplewicz et al (2022) Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell 40 1111 PMID: 36113478

If you know of a relevant reference for Imipramine hydrochloride, please let us know.

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