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Imiquimod

Cat. No. 3700 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Toll-like receptor 7 (TLR7) agonist
别名： R 837
化学名： 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Imiquimod

Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.

技术数据 for Imiquimod

分子量 240.3
公式 C14H16N4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 99011-02-6
PubChem ID 57469
InChI Key DOUYETYNHWVLEO-UHFFFAOYSA-N
Smiles CC(C)CN2C=NC1=C(N)N=C3C(C=CC=C3)=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Imiquimod

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.2 5 温和加热

制备储备液 for Imiquimod

以下数据基于产品分子量 240.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 83.23 mL 416.15 mL 832.29 mL
0.25 mM 16.65 mL 83.23 mL 166.46 mL
0.5 mM 8.32 mL 41.61 mL 83.23 mL
2.5 mM 1.66 mL 8.32 mL 16.65 mL

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参考文献 for Imiquimod

参考文献是支持产品生物活性的出版物。

Schon and Schon (2007) The antitumoral mode of action of imiq. and other imidazoquinolines. Curr.Med.Chem. 14 681 PMID: 17346155

Averett et al (2007) The pharmacology of endosomal TLR agonists in viral disease. Biochem.Soc.Trans. 35 1468 PMID: 18031247

Syed et al (2001) A review of the applications of imiquimod: a novel immune response modifier. Exp.Opin.Pharmacother. 2 877

If you know of a relevant reference for Imiquimod, please let us know.

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关键词: Imiquimod, Imiquimod supplier, Toll-like, receptors, 7, TLR7, agonists, R837, R, 837, Receptors, Non-selective, Antivirals, 3700, Tocris Bioscience

4 篇 Imiquimod 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Imiquimod 的部分引用包括：

Jian et al (2021) Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis. Nat Commun 12 4546 PMID: 34315884

Zoltan et al (2022) Presence of TRPA1 Modifies CD4+/CD8+ T Lymphocyte Ratio and Activation. Pharmaceuticals (Basel) 15 PMID: 35056114

Qian et al (2020) Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip. Elife 9 PMID: 32096759

Erick M et al (2020) Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways. Cell Rep 30 4399-4417.e7 PMID: 32234476

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Pathways for Imiquimod

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.