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Submit ReviewINCB 024360-analog
说明： Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
化学名： 4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
纯度： ≥99% (HPLC)
生物活性 for INCB 024360-analog
INCB 024360-analog is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.
化合物库 for INCB 024360-analog
INCB 024360-analog is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for INCB 024360-analog
| 分子量 | 271.64 |
| 公式 | C9H7ClFN5O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 914471-09-3 |
| PubChem ID | 11978742 |
| InChI Key | MUVQOOPKPBEAJZ-VQHVLOKHSA-N |
| Smiles | O/N=C(NC1=CC(Cl)=C(F)C=C1)/C2=NON=C2N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for INCB 024360-analog
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 27.16 | 100 | |
| ethanol | 27.16 | 100 |
制备储备液 for INCB 024360-analog
以下数据基于产品分子量 271.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.68 mL | 18.41 mL | 36.81 mL |
| 5 mM | 0.74 mL | 3.68 mL | 7.36 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.68 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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产品说明书 for INCB 024360-analog
参考文献 for INCB 024360-analog
参考文献是支持产品生物活性的出版物。
Weinmann (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578
Yue et al (2009) Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 52 7364 PMID: 19507862
Dounay et al (2015) Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 58 8762 PMID: 26207924
If you know of a relevant reference for INCB 024360-analog, please let us know.
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关键词: INCB 024360-analog, INCB 024360-analog supplier, 1, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, 2,3, dioxygenase, Immune, Checkpoints, 6007, Tocris Bioscience
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