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Submit ReviewIndomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.
分子量 | 357.79 |
公式 | C19H16ClNO4 |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 53-86-1 |
PubChem ID | 3715 |
InChI Key | CGIGDMFJXJATDK-UHFFFAOYSA-N |
Smiles | COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
ethanol | 17.89 | 50 温和加热 | |
DMSO | 35.78 | 100 |
以下数据基于产品分子量 357.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.79 mL | 13.97 mL | 27.95 mL |
5 mM | 0.56 mL | 2.79 mL | 5.59 mL |
10 mM | 0.28 mL | 1.4 mL | 2.79 mL |
50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
参考文献是支持产品生物活性的出版物。
Palomer et al (2002) Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 45 1402 PMID: 11906281
Shen and Winter (1977) Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 12 90 PMID: 343530
Walters and Willoughby (1965) Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 90 641 PMID: 5849618
Gordon et al (2020) A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 583 PMID: 32353859
If you know of a relevant reference for Indomethacin, please let us know.
关键词: Indomethacin, Indomethacin supplier, Cyclooxygenase, inhibitors, inhibits, COX-1, COX-2, Oxygenases, Oxidases, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Coronavirus, 1708, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Indomethacin 的部分引用包括:
Allen et al (2015) DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol 5 260 PMID: 26697402
Miller et al (2012) CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A 109 20602 PMID: 23185004
Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902
Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284 PMID: 24518663
Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Biomed Sci 35 5664 PMID: 25855180
Gonnermann et al (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology 4 e988460 PMID: 25949900
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.