主页 / 药理学 / Nuclear Receptors / PPARs / PPARγ / PPARγ Partial Agonists / INT 131

INT 131

Cat. No. 7423 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： PPARγ partial agonist
化学名： 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for INT 131

INT 131 is a potent and selective PPARγ partial agonist (EC50 = 4 nM; Ki = 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.

技术数据 for INT 131

分子量 514.21
公式 C21H12Cl4N2O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 315224-26-1
PubChem ID 10229498
InChI Key NMRWDFUZLLQSBN-UHFFFAOYSA-N
Smiles O=S(=O)(NC1=CC(Cl)=C(OC2=CN=C3C=CC=CC3=C2)C(Cl)=C1)C4=CC=C(Cl)C=C4Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for INT 131

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.57 5
ethanol 2.57 5

制备储备液 for INT 131

以下数据基于产品分子量 514.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 38.89 mL 194.47 mL 388.95 mL
0.25 mM 7.78 mL 38.89 mL 77.79 mL
0.5 mM 3.89 mL 19.45 mL 38.89 mL
2.5 mM 0.78 mL 3.89 mL 7.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for INT 131

参考文献是支持产品生物活性的出版物。

Frkic et al (2017) Structure-activity relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) analogs for PPARγ-targeted antidiabetics. J.Med.Chem. 60 4584 PMID: 28485590

Motani et al (2009) INT131: a selective modulator of PPARγ. J.Mol.Biol. 386 1301 PMID: 19452630

If you know of a relevant reference for INT 131, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 PPARγ Partial Agonists

关键词: INT 131, INT 131 supplier, INT131, PPARγ, PPARgamma, partial, agonists, antidiabetics, agent, Peroxisome, Proliferator-activating, Receptors, in, vivo, diabetes, 7423, Tocris Bioscience

篇 INT 131 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 INT 131 的引用文献。 您是否知道使用了 Tocris INT 131 的优秀论文？ 请告知我们.

INT 131 的评论

目前没有该产品的评论。 Be the first to review INT 131 and earn rewards!

Have you used INT 131?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review