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iP300v

Cat. No. 7584 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Negative control for iP300w (Cat. No. 7270)
化学名： (1'R,3'S)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide
纯度： ≥98% (HPLC)
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for iP300v

iP300v is a negative control for iP300w (Cat. No. 7270)

技术数据 for iP300v

分子量 618.55
公式 C29H27F5N6O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2763218-94-4
InChI Key SWXCHCQCWFXILM-YRTQXHIJSA-N
Smiles O=C(NC)CN(N=C1)C=C1C(C=C2)=CC3=C2[C@](N4)(C[C@@H]3F)C(N(CC(N(CC5=CC=C(F)C=C5)[C@@H](C)C(F)(F)F)=O)C4=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for iP300v

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 61.85 100

制备储备液 for iP300v

以下数据基于产品分子量 618.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.62 mL 8.08 mL 16.17 mL
5 mM 0.32 mL 1.62 mL 3.23 mL
10 mM 0.16 mL 0.81 mL 1.62 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for iP300v

参考文献是支持产品生物活性的出版物。

Bosnakovski et al (2019) A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death. Sci.Adv. 5 eaaw7781 PMID: 31535023

Bosnakovski et al (2021) Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma. Oncogenesis 10 68

If you know of a relevant reference for iP300v, please let us know.

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关键词: iP300v, iP300v supplier, HAT, Histone, Acetyltransferases, KAT, Lysine, Aceyltransferases, p300, CBP, negative, control, 7584, Tocris Bioscience

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Epigenetics Scientific Review

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