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说明： OX2 antagonist; orally bioavailable
化学名： 2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one
纯度： ≥98% (HPLC)
生物活性 for IPSU
OX2 receptor antagonist. Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. Decreases activity and increases sleep time in mice during the active phase, without affecting REM/NREM balance. Orally bioavailable. Brain penetrant.
技术数据 for IPSU
| 分子量 | 405.49 |
| 公式 | C23H27N5O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1373765-19-5 |
| PubChem ID | 56970858 |
| InChI Key | PCMHOSYCWRRHTG-UHFFFAOYSA-N |
| Smiles | COC1=CC=NC(N2CCC3(C(N(CC4=CNC5=C4C=CC=C5)CCC3)=O)CC2)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for IPSU
参考文献 for IPSU
参考文献是支持产品生物活性的出版物。
Hoyer et al (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Front.Neurosci. 7 230 PMID: 24376396
Betschart et al (2013) Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J.Med.Chem. 56 7590 PMID: 23964859
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关键词: IPSU, IPSU supplier, OX2, receptors, antagonists, antagonism, orexins, sleep, orally, bioavailable, brain, penetrant, Receptor, 5645, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.