OX2 Receptors
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness.
OX2 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 2142 | [Ala11,D-Leu15]-Orexin B |
| Potent and selective OX2 agonist | |
| 6739 | YNT 185 |
| Potent and selective OX2 agonist | |
OX2 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 4558 | EMPA |
| Highly potent and selective OX2 antagonist; brain penetrant | |
| 4317 | JNJ 10397049 |
| Selective OX2 antagonist | |
| 3371 | TCS OX2 29 |
| Potent and selective OX2 antagonist | |
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B. The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).
External sources of pharmacological information for OX2 Receptors :
Literature for OX2 Receptors
Tocris offers the following scientific literature for OX2 Receptors to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
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