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IRL-2500

Cat. No. 1838 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1838 has been discontinued.

View all ET<sub>B</sub> Receptors products.
说明： Potent ETB antagonist
化学名： N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-L-tryptophan
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for IRL-2500

IRL-2500 is a potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.

化合物库 for IRL-2500

IRL-2500 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for IRL-2500

分子量 573.69
公式 C36H35N3O4
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 169545-27-1
PubChem ID 5311192
InChI Key UZDORQWMYRRLQV-JHOUSYSJSA-N
Smiles O=C([C@@H](CC4=CC=C(C5=CC=CC=C5)C=C4)N(C)C(C3=CC(C)=CC(C)=C3)=O)N[C@H]([C@@](O)=O)CC1=CNC2=C1C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for IRL-2500

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for IRL-2500

参考文献是支持产品生物活性的出版物。

Balwierczak et al (1995) Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500. J.Cardiovasc.Pharmacol. 26 S393 PMID: 8587424

Leung et al (2002) Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ETB receptors. J.Cardiovasc.Pharmacol. 39 533 PMID: 11904527

Webb et al (1995) Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats. J.Cardiovasc.Pharmacol. 26 S389 PMID: 8587423

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关键词: IRL-2500, IRL-2500 supplier, Potent, ETB, antagonists, Receptors, Endothelin, IRL2500, 1838, Tocris Bioscience

1 篇 IRL-2500 的引用文献

引用文献是使用了 Tocris 产品的出版物。 IRL-2500 的部分引用包括：

Merlen et al (2013) Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes. J Mol Cell Cardiol 62 189 PMID: 23756157

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