Irsogladine maleate

Name: Irsogladine maleate
Brand: Tocris Bioscience
SKU: 2504

Cat. No. 2504 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2504 has been discontinued.

View all Phosphodiesterases products.

说明： PDE4 inhibitor; antiulcer agent

别名： MN 1695

化学名： 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Irsogladine maleate

Irsogladine maleate is a phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

技术数据 for Irsogladine maleate

分子量	372.18
公式	C₉H₇Cl₂N₅.C₄H₄O₄
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	84504-69-8
PubChem ID	5282435
InChI Key	PJLVTVAIERNDEQ-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.NC1=NC(=NC(N)=N1)C1=CC(Cl)=CC=C1Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Irsogladine maleate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Irsogladine maleate

参考文献是支持产品生物活性的出版物。

Nozaki et al (2004) Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res.Treat. 83 195 PMID: 14758089

Kyoi et al (2004) Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J.Pharmacol.Sci. 95 321 PMID: 15272207

Kyoi et al (2004) Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 76 71 PMID: 15501481

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关键词: Irsogladine maleate, Irsogladine maleate supplier, PDE4, inhibitors, inhibits, antiulcer, agent, Phosphodiesterases, MN1695, MN, 1695, 2504, Tocris Bioscience

篇 Irsogladine maleate 的引用文献

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