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Submit ReviewIschemin sodium salt
说明： CBP inhibitor; cell permeable
化学名： 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt
纯度： ≥99% (HPLC)
生物活性 for Ischemin sodium salt
Ischemin sodium salt is a CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.
技术数据 for Ischemin sodium salt
| 分子量 | 357.36 |
| 公式 | C15H16N3O4SNa |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| PubChem ID | 64983 |
| InChI Key | XWNMORIHKRROGW-UHFFFAOYSA-N |
| Smiles | CC1=CC(/N=N/C2=C(C)C=C(C)C(S(=O)(O[Na])=O)=C2)=C(N)C=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ischemin sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 35.74 | 100 | |
| DMSO | 35.74 | 100 |
制备储备液 for Ischemin sodium salt
以下数据基于产品分子量 357.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for Ischemin sodium salt
参考文献 for Ischemin sodium salt
参考文献是支持产品生物活性的出版物。
Borah et al (2011) A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem.Biol. 18 531 PMID: 21513889
If you know of a relevant reference for Ischemin sodium salt, please let us know.
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关键词: Ischemin sodium salt, Ischemin sodium salt supplier, CBP, bromodomain, inhibitors, inhibits, p53, interaction, cell, permeable, 1357059, 00, 7, Bromodomains, 4695, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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